Glucophage and Nucala drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucophage (metformin hydrochloride) and Nucala (mepolizumab). Common drug interactions include fall among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Glucophage and Nucala. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Nucala?

Nucala has active ingredients of mepolizumab. eHealthMe is studying from 26,883 Nucala users. Check the latest studies of Nucala.

On Jul, 10, 2026

17 people who take Glucophage and Nucala together, and have interactions are studied.

Glucophage and Nucala drug interactions.

What are the common drug interactions of Glucophage and Nucala, by gender? *:

female:

Fall
Spinal compression fracture (fracture due to spinal compression on bone)
Wrist fracture
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Surgery
Drug hypersensitivity
Back pain
Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Back pain
Blood bilirubin increased
Blood urea increased
Dyspnoea (difficult or laboured respiration)
Intervertebral disc protrusion (spinal disc protrusion)
Photosensitivity reaction
Spinal stenosis (narrowing of spinal column)

What are the common drug interactions of Glucophage and Nucala, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Groin pain
Joint swelling
Pain in extremity
Peripheral swelling

60+:

Back pain
Blood bilirubin increased
Blood urea increased
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Heart rate increased
Intervertebral disc protrusion (spinal disc protrusion)
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 64.71%
Asthma: 3 people, 17.65%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.88%
Vasomotor Rhinitis (stuffy nose): 1 person, 5.88%
Seasonal Allergy (allergic condition due to certain season): 1 person, 5.88%
Respiratory Tract Congestion (blockage on respiratory system): 1 person, 5.88%
Nasal Polyps (masses that develop in the lining of the nose): 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%
Motion Sickness (travel sickness): 1 person, 5.88%
Hypersensitivity: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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