Glucosamine and B6 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucosamine (glucosamine) and B6 (pyridoxine (vitamin b6)). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Glucosamine and B6. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Glucosamine?

Glucosamine has active ingredients of glucosamine. It is often used in joint pain. eHealthMe is studying from 15,547 Glucosamine users. Check the latest studies of Glucosamine.

What is B6?

B6 has active ingredients of pyridoxine (vitamin b6). eHealthMe is studying from 1,043 B6 users. Check the latest studies of B6.



On Jul, 26, 2026

14 people who take Glucosamine and B6 together, and have interactions are studied.

Glucosamine and B6 drug interactions.

What are the common drug interactions of Glucosamine and B6, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Insomnia (sleeplessness)
  3. Neuropathy peripheral (surface nerve damage)
  4. Alopecia (absence of hair from areas of the body)
  5. Decreased appetite
  6. Diarrhoea
  7. Spinal osteoarthritis (joint cartilage loss in spine)
  8. Asthenia (weakness)
  9. Burning sensation
  10. Confusional state

male:

  1. Fatigue (feeling of tiredness)
  2. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  3. Back pain
  4. Confusional state
  5. Gait disturbance
  6. Hunger
  7. Hypotonia (low muscle tone)
  8. Injection site discolouration
  9. Injection site reaction
  10. Visual impairment

What are the common drug interactions of Glucosamine and B6, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Breast cancer female
  2. Neoplasm malignant (cancer tumour)
  3. Thyroid cancer
  4. Uterine cancer

50-59:

  1. Diarrhoea
  2. Abdominal discomfort
  3. Abdominal pain
  4. Autoimmune pancreatitis (autoimmune pancreatitis (aip) is an increasingly recognized type of chronic pancreatitis)
  5. Insomnia (sleeplessness)
  6. Joint swelling
  7. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  8. Pancreatitis (inflammation of pancreas)
  9. Vomiting

60+:

  1. Fatigue (feeling of tiredness)
  2. Neuropathy peripheral (surface nerve damage)
  3. Pain
  4. Adverse drug reaction
  5. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  6. Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
  7. Anxiety
  8. Aphasia (damage to the parts of the brain that control language)
  9. Balance disorder
  10. Blood pressure increased

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
  2. Neuropathy Peripheral (surface nerve damage): 2 people, 14.29%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
  4. Gastrointestinal Stromal Tumor: 2 people, 14.29%
  5. White Blood Cell Count Decreased: 1 person, 7.14%
  6. High Blood Cholesterol: 1 person, 7.14%
  7. Breast Cancer Metastatic: 1 person, 7.14%
  8. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 7.14%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%
  10. Diabetes: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Glucosamine and B6:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucosamine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of B6:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucosamine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between B6 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on glucosamine and pyridoxine (vitamin b6) (the active ingredients of Glucosamine and B6, respectively), and Glucosamine and B6 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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