Glucovance and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucovance (glyburide; metformin hydrochloride) and Bextra (valdecoxib). Common drug interactions include weight decreased among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Glucovance and Bextra. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Jul, 23, 2026

61 people who take Glucovance and Bextra together, and have interactions are studied.

Glucovance and Bextra drug interactions.

What are the common drug interactions of Glucovance and Bextra, by gender? *:

female:

Weight decreased
Alopecia (absence of hair from areas of the body)
Back pain
Depression
Diarrhoea
Dyspepsia (indigestion)
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Vomiting

male:

Dizziness
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Sleep disorder
Spinal disorder (disease of spine a back bone)
Anxiety
Asthenia (weakness)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the common drug interactions of Glucovance and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood glucose increased

30-39:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest injury
Dysmenorrhoea (painful menstruation)
Essential hypertension (primary hypertension)
Excoriation (to tear or wear off the skin of)
Myositis (inflammation of the muscles)
Road traffic accident
Sternal fracture
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Trigonitis (a condition of inflammation of the trigone region of the bladder)

40-49:

Back pain
Fatigue (feeling of tiredness)
Haematoma (collection of blood outside the blood vessels)
Oedema peripheral (superficial swelling)
Blood cholesterol increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Epistaxis (bleed from the nose)

50-59:

Rash
Weight decreased
Alanine aminotransferase increased
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Breast microcalcification (deposits of calcium that can be seen on a mammogram of the breast)

60+:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hypersensitivity
Osteomyelitis (infection of bone)
Osteonecrosis (death of bone)
Spinal disorder (disease of spine a back bone)
Anxiety
Chronic kidney disease
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 11.48%
Type 2 Diabetes: 6 people, 9.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.56%
Depression: 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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