Glumetza and Doxycycline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glumetza (metformin hydrochloride) and Doxycycline (doxycycline hyclate). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Glumetza and Doxycycline. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Glumetza?

Glumetza has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,968 Glumetza users. Check the latest studies of Glumetza.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

On Jul, 06, 2026

16 people who take Glumetza and Doxycycline together, and have interactions are studied.

Glumetza and Doxycycline drug interactions.

What are the common drug interactions of Glumetza and Doxycycline, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Chest discomfort
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Gangrene (body tissue dies)
Headache (pain in head)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Anxiety
Bone density decreased
Depression
Emotional distress
Pain
Renal failure (kidney dysfunction)

What are the common drug interactions of Glumetza and Doxycycline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Chest discomfort
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Upper respiratory tract infection

50-59:

Chronic kidney disease
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Depression
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Multiple fractures
Osteoporosis (bones weak and more likely to break)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal tubular necrosis (death of kidney tubules)
Ascites (accumulation of fluid in the abdominal cavity)
Hepatic steatosis (fatty liver disease)
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 56.25%
High Blood Pressure: 8 people, 50.00%
Fungal Infection: 7 people, 43.75%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 43.75%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 37.50%
Depression: 5 people, 31.25%
High Blood Cholesterol: 5 people, 31.25%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 31.25%
Indigestion: 4 people, 25.00%
Laxative Supportive Care: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

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