Gralise and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gralise (gabapentin) and Fluconazole (fluconazole). Common drug interactions include sleep apnoea syndrome among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Gralise and Fluconazole. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Gralise?

Gralise has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 4,282 Gralise users. Check the latest studies of Gralise.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

35 people who take Gralise and Fluconazole together, and have interactions are studied.

Gralise and Fluconazole drug interactions.

What are the common drug interactions of Gralise and Fluconazole, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)
Nausea (feeling of having an urge to vomit)
Pain
Back pain
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Headache (pain in head)
Hypersensitivity
Migraine (headache)

male:

Cardiac arrest
Herpes zoster
Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Gralise and Fluconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Blood prolactin decreased
Depression
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pelvic inflammatory disease
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)

40-49:

Anxiety
Back pain
Nausea (feeling of having an urge to vomit)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Nephrolithiasis (calculi in the kidneys)
Hip arthroplasty
Surgery

50-59:

Abdominal discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colon cancer
Diarrhoea
Escherichia infection (bacterial infection by escherichia coli)
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Nausea (feeling of having an urge to vomit)
Oesophageal disorder (disease of oesophagus)
Sinusitis (inflammation of sinus)

60+:

Herpes zoster
Blood glucose increased
Headache (pain in head)
Hirsutism (abnormal growth of hair on a person's face and body, esp. on a woman)
Injection site pain
Psoriasis (immune-mediated disease that affects the skin)
Swelling
Tooth loss
Vitreous floaters (spots before the eyes)
Weight increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 40.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 40.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 14.29%
Immunodeficiency Common Variable: 4 people, 11.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 11.43%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 8.57%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 5.71%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 2 people, 5.71%
Muscle Spasms (muscle contraction): 2 people, 5.71%
Migraine (headache): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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