Gralise and Morphine drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Gralise (gabapentin) and Morphine (morphine sulfate). Common drug interactions include nystagmus among females and weight decreased among males.
The phase IV clinical study analyzes what interactions people have when they take Gralise and Morphine. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.
What is Gralise?
Gralise has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 4,282 Gralise users. Check the latest studies of Gralise.
What is Morphine?
Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.
75 people who take Gralise and Morphine together, and have interactions are studied.

What are the common drug interactions of Gralise and Morphine, by gender? *:
female:
- Nystagmus (a condition of involuntary eye movement)
- Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
- Tonic clonic movements (generalized seizure that affects the entire brain)
- Visual impairment
- Hypotension (abnormally low blood pressure)
- Arthralgia (joint pain)
- Dizziness
- Gait disturbance
- Malaise (a feeling of general discomfort or uneasiness)
- Respiratory tract congestion (blockage on respiratory system)
male:
- Weight decreased
- Abnormal behaviour
- Memory impairment
- Rash
- Skin discolouration (change of skin colour)
- Spider vein (small dilated blood vessels near the surface of the skin)
- Stress
- Vomiting
- Wound
- Gait disturbance
What are the common drug interactions of Gralise and Morphine, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Alopecia (absence of hair from areas of the body)
- Anxiety
- Aphonia (inability to produce voice)
- Cough
- Depression
- Diarrhoea
- Dry skin
- Dry throat
- Fall
- Incontinence (lack of moderation or self-control)
40-49:
- Drug ineffective
- Surgery
- Alopecia (absence of hair from areas of the body)
- Chronic kidney disease
- Platelet count decreased
- Renal failure (kidney dysfunction)
- Tooth loss
50-59:
- Vomiting
- Neuropathy peripheral (surface nerve damage)
- Aphasia (damage to the parts of the brain that control language)
- Decreased appetite
- Mydriasis (a dilation of the pupil)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Body temperature increased
- Chills (felling of cold)
- Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
60+:
- Insomnia (sleeplessness)
- Memory impairment
- Skin discolouration (change of skin colour)
- Spider vein (small dilated blood vessels near the surface of the skin)
- Stress
- Vomiting
- Weight decreased
- Wound
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
What are the existing conditions these people have? *
- Depression: 17 people, 22.67%
- Stress And Anxiety: 13 people, 17.33%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 12.00%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 10.67%
- Procedural Pain: 8 people, 10.67%
- Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 8 people, 10.67%
- Burkitt Lymphoma (cancer of the lymphatic system): 8 people, 10.67%
- Nausea (feeling of having an urge to vomit): 8 people, 10.67%
- Breakthrough Pain: 7 people, 9.33%
- High Blood Cholesterol: 7 people, 9.33%
* Approximation only. Some reports may have incomplete information.
Do you take Gralise and Morphine?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Gralise and Morphine:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Gralise:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Morphine:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Gralise and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Morphine and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
- Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
- Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .
- de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
- Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
- Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on gabapentin and morphine sulfate (the active ingredients of Gralise and Morphine, respectively), and Gralise and Morphine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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