Grapes and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Grapes (grape) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include nausea among females and addison's disease among males.

The phase IV clinical study analyzes what interactions people have when they take Grapes and Benadryl. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Grapes?

Grapes has active ingredients of grape. eHealthMe is studying from 234 Grapes users. Check the latest studies of Grapes.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 14, 2026

18 people who take Grapes and Benadryl together, and have interactions are studied.

What are the common drug interactions of Grapes and Benadryl, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Rash
Anxiety
Asthenia (weakness)
Chest discomfort
Dizziness
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Pain
Therapeutic response unexpected

male:

Addison's disease (addison's disease, a hormonal disorder disease)
Cardiac arrest
Rhinorrhoea (watery mucus discharge from the nose)
Cataract (clouding of the lens inside the eye)
Decreased immune responsiveness
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Osteoporosis (bones weak and more likely to break)
Pneumonia

What are the common drug interactions of Grapes and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Post lumbar puncture syndrome

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dizziness
Abnormal dreams
Anxiety
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Rash
Therapeutic response unexpected
Vision blurred

60+:

Chest discomfort
Pain
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Oral pain
Rash
Sensitivity of teeth
Tremor (trembling or shaking movements in one or more parts of your body)
Agitation (state of anxiety or nervous excitement)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 38.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 22.22%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Parkinson's Disease: 1 person, 5.56%
On And Off Phenomenon: 1 person, 5.56%
Neoplasm Malignant (cancer tumour): 1 person, 5.56%
Neck Pain: 1 person, 5.56%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%
Ill-Defined Disorder: 1 person, 5.56%
Hypersensitivity: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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