Hc and Magnesium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Magnesium (magnesium). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Magnesium. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Magnesium?

Magnesium has active ingredients of magnesium. It is often used in constipation. eHealthMe is studying from 121,145 Magnesium users. Check the latest studies of Magnesium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

69 people who take Hc and Magnesium together, and have interactions are studied.

What are the common drug interactions of Hc and Magnesium, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Pain
Pruritus (severe itching of the skin)
Abdominal pain
Ageusia (loss of taste functions of the tongue)
Anaemia (lack of blood)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

male:

Fatigue (feeling of tiredness)
Pain
Hospitalisation
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Back pain
Cardiac disorder
Death
Dyspnoea (difficult or laboured respiration)
Hepatic enzyme increased

What are the common drug interactions of Hc and Magnesium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Adenoma benign (non-cancerous tumour -secreting)
Adnexa uteri cyst (ovarian cysts)
Allergic sinusitis
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve sclerosis (narrowing of the aortic valve)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

30-39:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Rectal ulcer (ulcer of rectum)
Anxiety
Aphthous ulcer (mouth ulcer)
Blindness transient (sudden loss of vision)
Blood pressure increased
Dyslexia (disorders that involve difficulty in learning to read or interpret words, letters, and other symbols)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Headache (pain in head)
Hot flush (sudden feelings of heat)

40-49:

Cardiac disorder
Leukoencephalopathy (disease of the white matter in the brain)
Nasopharyngitis (inflammation of the nasopharynx)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Anxiety
Arthralgia (joint pain)
Back pain
Chronic kidney disease
Confusional state
Crying
Disease progression
Disturbance in attention
Dry eye (lack of adequate tears)
Dry mouth

60+:

Diarrhoea
Urinary tract infection
Anaemia (lack of blood)
Asthenia (weakness)
Death
Dehydration (dryness resulting from the removal of water)
Dizziness
Glossodynia (a burning or painful sensation in the tongue)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 17.39%
Pain: 10 people, 14.49%
Immunodeficiency Common Variable: 10 people, 14.49%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 13.04%
Nausea (feeling of having an urge to vomit): 7 people, 10.14%
Drowsiness: 7 people, 10.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.70%
Nausea And Vomiting: 5 people, 7.25%
High Blood Pressure: 5 people, 7.25%
Procedural Pain: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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