Hc and Morphine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Morphine sulfate (morphine sulfate). Common drug interactions include arthralgia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Morphine sulfate. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,261 Morphine sulfate users. Check the latest studies of Morphine sulfate.



On Jul, 19, 2026

45 people who take Hc and Morphine sulfate together, and have interactions are studied.

Hc and Morphine sulfate drug interactions.

What are the common drug interactions of Hc and Morphine Sulfate, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Depression
  4. Haematochezia (passage of stools containing blood)
  5. Herpes zoster
  6. Laceration (tearing of soft body tissue)
  7. Nephrolithiasis (calculi in the kidneys)
  8. Abdominal pain
  9. Acute respiratory failure
  10. Chest pain

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Haemorrhage (bleeding)
  5. Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
  6. Herpes simplex (herpes simplex is a common viral infection)
  7. Herpes zoster
  8. Hypophagia (reduced food intake)
  9. Injury
  10. Lung neoplasm malignant (cancer tumour of lung)

What are the common drug interactions of Hc and Morphine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anxiety
  2. Diarrhoea
  3. Dizziness
  4. Haematochezia (passage of stools containing blood)
  5. Laceration (tearing of soft body tissue)
  6. Nephrolithiasis (calculi in the kidneys)
  7. Abdominal pain
  8. Actinic keratosis (skin disease due to sun exposure)
  9. Acute respiratory failure
  10. Altered state of consciousness (altered state of mind)

30-39:

  1. Rectal ulcer (ulcer of rectum)

40-49:

  1. Hypokalaemia (low potassium)
  2. Localised infection (infection at the single location)
  3. Nail bed tenderness
  4. Neuropathy peripheral (surface nerve damage)
  5. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
  6. Skin discolouration (change of skin colour)
  7. Vaginal haemorrhage (vaginal bleeding)
  8. Arthralgia (joint pain)
  9. Balance disorder
  10. Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)

50-59:

  1. Atypical femur fracture
  2. Humerus fracture (injury to the upper arm bone)
  3. Anaemia (lack of blood)

60+:

  1. Haemorrhage (bleeding)
  2. Pneumonia
  3. Bone pain
  4. Cardiomegaly (increased size of heart than normal)
  5. Compression fracture (fracture due to pressure caused by injury)
  6. Cough
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Diarrhoea
  9. Discomfort
  10. Dizziness

What are the existing conditions these people have? *

  1. Neoplasm Malignant (cancer tumour): 8 people, 17.78%
  2. Bone Disorder: 8 people, 17.78%
  3. Acetabulum Fracture (socket of the hip joint- fracture): 8 people, 17.78%
  4. Breast Cancer Metastatic: 5 people, 11.11%
  5. Osteoporosis (bones weak and more likely to break): 4 people, 8.89%
  6. Nausea (feeling of having an urge to vomit): 4 people, 8.89%
  7. Stress And Anxiety: 3 people, 6.67%
  8. High Blood Pressure: 3 people, 6.67%
  9. Chest Pain: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Hc and Morphine sulfate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hc and Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hc:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hc and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Morphine sulfate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and morphine sulfate (the active ingredients of Hc and Morphine sulfate, respectively), and Hc and Morphine sulfate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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