Hc and Nicotine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Nicotine (nicotine). Common drug interactions include fatigue among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Nicotine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

On Aug, 08, 2026

12 people who take Hc and Nicotine together, and have interactions are studied.

What are the common drug interactions of Hc and Nicotine, by gender? *:

female:

Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hangover
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain
Injection site reaction
Injection site swelling
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle rupture (tear in muscle)
Muscle twitching

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Back pain
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bladder obstruction
Blood pressure decreased
Blood pressure fluctuation
Blood pressure increased

What are the common drug interactions of Hc and Nicotine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Confusional state
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle twitching
Suicidal ideation

40-49:

Injection site reaction
Injection site swelling
Muscle rupture (tear in muscle)
Myalgia (muscle pain)
Peripheral swelling
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Dysstasia (difficulty in standing)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain

50-59:

Disease progression

60+:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Pneumonia
Pulmonary congestion (congestion in the lungs)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 33.33%
Depression: 3 people, 25.00%
Dizziness: 3 people, 25.00%
High Blood Pressure: 2 people, 16.67%
Hypotonia (low muscle tone): 2 people, 16.67%
Drowsiness: 2 people, 16.67%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 2 people, 16.67%
Cough: 2 people, 16.67%
Migraine (headache): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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