Hc and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Wellbutrin (bupropion hydrochloride). Common drug interactions include cough among females and vertigo among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Wellbutrin. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 06, 2026

41 people who take Hc and Wellbutrin together, and have interactions are studied.

What are the common drug interactions of Hc and Wellbutrin, by gender? *:

female:

Cough
Temperature intolerance (inability to go in temperature)
Chest pain
Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Myalgia (muscle pain)
Sneezing
Palpitations (feelings or sensations that your heart is pounding or racing)
Arthralgia (joint pain)

male:

Vertigo
Dizziness
Malignant neoplasm progression (cancer tumour came back)
Neoplasm progression (growth of tumour)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Pain in extremity
Pain
Anaemia (lack of blood)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Hc and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Dizziness
Muscle twitching
Activities of daily living impaired
Arthralgia (joint pain)
Confusional state
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Dysstasia (difficulty in standing)
Emotional distress

40-49:

Apnoea (suspension of external breathing)
Blood folate increased
Blood sodium increased
Carbon dioxide decreased
Emotional distress
Fatigue (feeling of tiredness)
Glomerular filtration rate decreased
High density lipoprotein increased
Homeless
Injury

50-59:

Sinusitis (inflammation of sinus)
Thirst
Uterine fibroids (benign growths of the muscle inside the uterus)
Vaginal haemorrhage (vaginal bleeding)
Chronic kidney disease
Pain
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Drug hypersensitivity
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

60+:

Chest pain
Malaise (a feeling of general discomfort or uneasiness)
Deafness unilateral
Pulmonary hypertension (increase in blood pressure in the lung artery)
Abdominal discomfort
Abdominal pain
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arthralgia (joint pain)
Blood creatine increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 21.95%
Pain: 8 people, 19.51%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 8 people, 19.51%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 17.07%
Sleep Disorder: 6 people, 14.63%
Migraine (headache): 6 people, 14.63%
Itching: 5 people, 12.20%
Headache (pain in head): 5 people, 12.20%
Neuralgia (pain in one or more nerves): 4 people, 9.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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