Hctz and Lialda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hctz (hydrochlorothiazide) and Lialda (mesalamine). Common drug interactions include injection site pain among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Hctz and Lialda. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

What is Lialda?

Lialda has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 10,199 Lialda users. Check the latest studies of Lialda.

On Jul, 15, 2026

48 people who take Hctz and Lialda together, and have interactions are studied.

What are the common drug interactions of Hctz and Lialda, by gender? *:

female:

Injection site pain
Injection site streaking
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oropharyngeal pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

male:

Drug ineffective
Injection site pain
Prostate cancer
Septic shock (shock due to blood infection)
Abdominal adhesions (inflammation of abdomen)
Anaemia (lack of blood)
Blood alkaline phosphatase increased
Chest pain
Diarrhoea
Discomfort

What are the common drug interactions of Hctz and Lialda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Disturbance in attention
Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

40-49:

Erythema (redness of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Cholecystitis acute (rapid infection of gallbladder)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin discolouration (change of skin colour)

50-59:

Procedural pain
Pulmonary thrombosis (scarring in the lungs)
Rash
Rectal haemorrhage (bleeding from anus)
Renal cancer (cancer of kidney)
Tremor (trembling or shaking movements in one or more parts of your body)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Weight increased
White blood cell count increased
Chronic kidney disease

60+:

Memory impairment
Nerve injury
Rectal cancer (cancer of rectum)
Thyroid neoplasm (tumour of thyroid)
Ulcer
Disturbance in attention
Dry mouth
Frequent bowel movements
Glossodynia (a burning or painful sensation in the tongue)
Injection site pain

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 16 people, 33.33%
High Blood Cholesterol: 10 people, 20.83%
Stress And Anxiety: 10 people, 20.83%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 18.75%
Depression: 6 people, 12.50%
Pain: 6 people, 12.50%
Insomnia (sleeplessness): 5 people, 10.42%
Diabetes: 5 people, 10.42%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 10.42%
Asthma: 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

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