Herceptin and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Herceptin (trastuzumab) and Provera (medroxyprogesterone acetate). Common drug interactions include pleural effusion among females and angina unstable among males.

The phase IV clinical study analyzes what interactions people have when they take Herceptin and Provera. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Herceptin?

Herceptin has active ingredients of trastuzumab. It is often used in breast cancer. eHealthMe is studying from 42,205 Herceptin users. Check the latest studies of Herceptin.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

18 people who take Herceptin and Provera together, and have interactions are studied.

Herceptin and Provera drug interactions.

What are the common drug interactions of Herceptin and Provera, by gender? *:

female:

Pleural effusion (water on the lungs)
Dizziness
Anxiety
Chest pain
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Aortic valve incompetence
Biliary colic
Bone disorder
Bruxism (habitual grinding of the teeth, typically during sleep)
Cardiomyopathy (weakening of the heart muscle)

male:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Balance disorder
Biliary colic
Bone disorder
Bone swelling
Breath sounds absent
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)

What are the common drug interactions of Herceptin and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Anxiety
Emotional distress
Pain

40-49:

Alopecia (absence of hair from areas of the body)

50-59:

Biliary colic
Bone disorder
Bruxism (habitual grinding of the teeth, typically during sleep)
Cardiomyopathy (weakening of the heart muscle)
Dizziness
Electrocardiogram qt prolonged
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Impaired healing
Injury
Laryngeal oedema (swelling of larynx)

60+:

Chest pain
Dizziness
Disease progression
Drug ineffective
Dry skin
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Increased appetite
Muscular weakness (muscle weakness)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 9 people, 50.00%
High Blood Cholesterol: 8 people, 44.44%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 44.44%
High Blood Pressure: 8 people, 44.44%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%
Gastritis (inflammation of stomach): 1 person, 5.56%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.56%
Back Pain: 1 person, 5.56%
Bipolar Disorder (mood disorder): 1 person, 5.56%
Blood Pressure Abnormal: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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