Herceptin and Zyprexa drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Herceptin (trastuzumab) and Zyprexa (olanzapine). Common drug interactions include pain among females.
The phase IV clinical study analyzes what interactions people have when they take Herceptin and Zyprexa. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.
What is Herceptin?
Herceptin has active ingredients of trastuzumab. It is often used in breast cancer. eHealthMe is studying from 42,205 Herceptin users. Check the latest studies of Herceptin.
What is Zyprexa?
Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.
97 people who take Herceptin and Zyprexa together, and have interactions are studied.

What are the common drug interactions of Herceptin and Zyprexa, by gender? *:
female:
- Pain
- Pyrexia (fever)
- Gait disturbance
- Injury
- Dysarthria (speech disorder)
- Hypoaesthesia (reduced sense of touch or sensation)
- Osteoarthritis (a joint disease caused by cartilage loss in a joint)
- Toothache (tooth pain)
- Anaemia (lack of blood)
- Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
male:
n/a
What are the common drug interactions of Herceptin and Zyprexa, by age (0-1 to 60+)? *:
0-1:
- Bone marrow failure
2-9:
n/a
10-19:
- Abdominal mass (localized enlargement or swelling in the human abdomen)
- Abdominal pain
- Abdominal pain upper
- Actinomycosis (infection that causes sores, or abscesses)
- Albumin globulin ratio decreased
- Alopecia (absence of hair from areas of the body)
- Alveolitis (inflammation in the socket of a tooth)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anaemia (lack of blood)
- Angina pectoris (chest pain due to ischemia of the heart muscle)
20-29:
n/a
30-39:
- Pain
- Arthralgia (joint pain)
- Back pain
- Bone disorder
- Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
- Cervix carcinoma (cancer of cervix)
- Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
- Diarrhoea
- Dysarthria (speech disorder)
- Dyspnoea (difficult or laboured respiration)
40-49:
- Anaemia (lack of blood)
- Intervertebral disc protrusion (spinal disc protrusion)
- Pain
- Spinal osteoarthritis (joint cartilage loss in spine)
- Anaemia of malignant disease
- Axillary mass
- Back pain
- Deafness
- Dental caries
- Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
50-59:
- Oedema peripheral (superficial swelling)
- Osteonecrosis of jaw (death of bone of jaw)
- Osteoporosis (bones weak and more likely to break)
- Pain
- Upper respiratory tract infection
- General physical health deterioration (weak health status)
- Pyrexia (fever)
- Abdominal pain
- Albumin globulin ratio decreased
- Alveolitis (inflammation in the socket of a tooth)
60+:
- Pneumonia
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
- Anaemia (lack of blood)
- Arthralgia (joint pain)
- Back pain
- Biliary dilatation
- Bone disorder
- Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
- Bone loss
What are the existing conditions these people have? *
- Sleep Apnea Syndrome: 23 people, 23.71%
- Metastases To Bone (cancer spreads to bone): 22 people, 22.68%
- Bone Density Decreased: 15 people, 15.46%
- Mood Swings (an extreme or rapid change in mood): 14 people, 14.43%
- Depression: 14 people, 14.43%
- Sleep Disorder: 14 people, 14.43%
- Muscle Spasms (muscle contraction): 13 people, 13.40%
- Pain: 11 people, 11.34%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 11.34%
- Insomnia (sleeplessness): 11 people, 11.34%
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Herceptin and Zyprexa:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Herceptin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zyprexa:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Herceptin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyprexa and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
- Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .
- Saleh M, Bourcier T, Noel G, Speeg-Schatz C, Gaucher D, "Bilateral macular ischemia and severe visual loss following trastuzumab therapy", Acta Oncologica, 2011 Apr .
- Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
- Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .
- Saleh M, Bourcier T, Noel G, Speeg-Schatz C, Gaucher D, "Bilateral macular ischemia and severe visual loss following trastuzumab therapy", Acta Oncologica, 2011 Apr .
How the study uses the data?
The study uses data from the FDA. It is based on trastuzumab and olanzapine (the active ingredients of Herceptin and Zyprexa, respectively), and Herceptin and Zyprexa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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