Hetlioz and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hetlioz (tasimelteon) and Tylenol (acetaminophen). Common drug interactions include neuropathy peripheral among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Hetlioz and Tylenol. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Hetlioz?

Hetlioz has active ingredients of tasimelteon. eHealthMe is studying from 7,418 Hetlioz users. Check the latest studies of Hetlioz.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

81 people who take Hetlioz and Tylenol together, and have interactions are studied.

What are the common drug interactions of Hetlioz and Tylenol, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep disorder
Social avoidant behaviour (avoiding social connection a personality disorder)
Surgery
Therapeutic response unexpected
Visual impairment
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Insomnia (sleeplessness)

male:

Insomnia (sleeplessness)
Migraine (headache)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Thrombosis (formation of a blood clot inside a blood vessel)
Vomiting
Agitation (state of anxiety or nervous excitement)
Bradycardia (abnormally slow heart action)
Cardiac arrest

What are the common drug interactions of Hetlioz and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Vomiting

30-39:

Insomnia (sleeplessness)
Agitation (state of anxiety or nervous excitement)
Eye swelling
Intentional self-injury
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Wrist fracture

40-49:

Insomnia (sleeplessness)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Aggression
Decreased appetite
Mood swings (an extreme or rapid change in mood)
Poor quality sleep
Anxiety
Fall
Gait disturbance
Muscular weakness (muscle weakness)

50-59:

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Migraine (headache)
Upper respiratory tract infection
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Thrombosis (formation of a blood clot inside a blood vessel)
Abnormal dreams
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiac failure

60+:

Bacterial infection
Fall
Staphylococcal infection (an infection with staphylococcus bacteria)
Faecaloma (hard mass of fecal matter)
Gastric disorder (disease of stomach)
Nightmare (unpleasant dream)
Blood pressure increased
Confusional state
Dehydration (dryness resulting from the removal of water)
Dizziness

What are the existing conditions these people have? *

Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 23 people, 28.40%

* Approximation only. Some reports may have incomplete information.

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