Horizant and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Horizant (gabapentin enacarbil) and Botox (botulinum toxin type a). Common drug interactions include urticaria among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Horizant and Botox. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Horizant?

Horizant has active ingredients of gabapentin enacarbil. It is often used in restless leg syndrome. eHealthMe is studying from 2,051 Horizant users. Check the latest studies of Horizant.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

On Jul, 08, 2026

36 people who take Horizant and Botox together, and have interactions are studied.

What are the common drug interactions of Horizant and Botox, by gender? *:

female:

Urticaria (rash of round, red welts on the skin that itch intensely)
Accident
Adverse drug reaction
Anxiety
Chronic kidney disease
Depression
Disability
Drug ineffective
Pain
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Disturbance in attention
Dizziness
Enuresis (repeated inability to control urination)
Eructation (release of gas from the digestive tract)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gallbladder disorder
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Horizant and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased

30-39:

Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatitis (inflammation of the liver)
Hypophagia (reduced food intake)
Intracranial hypotension (low pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Nightmare (unpleasant dream)
Occipital neuralgia (a condition characterized by chronic pain in the upper neck)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

n/a

60+:

Dystonia (abnormal muscle tone)
Herpes zoster oticus (viral infection of the inner, middle, and external ear caused by varicella-zoster virus (vzv))
Light chain analysis increased
Muscle spasms (muscle contraction)
Pain in extremity

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 72.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 52.78%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.11%
Insomnia (sleeplessness): 3 people, 8.33%
Fatigue (feeling of tiredness): 3 people, 8.33%
Drowsiness: 3 people, 8.33%
Back Pain: 3 people, 8.33%
Rickets (softening of bones): 2 people, 5.56%
Rashes (redness): 2 people, 5.56%
Muscle Twitching: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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