Humalog and Combivir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Humalog (insulin lispro recombinant) and Combivir (lamivudine; zidovudine). Common drug interactions include multiple fractures among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Humalog and Combivir. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,127 Humalog users. Check the latest studies of Humalog.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

50 people who take Humalog and Combivir together, and have interactions are studied.

What are the common drug interactions of Humalog and Combivir, by gender? *:

female:

Multiple fractures
Osteoporosis (bones weak and more likely to break)
Renal injury (kidney injury)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Bone density decreased
Cushing's syndrome (obesity, a rounded face, increased fat)
Depression

male:

Anxiety
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Anaemia (lack of blood)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Gait disturbance
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Impaired work ability
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Humalog and Combivir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cushing's syndrome (obesity, a rounded face, increased fat)
Cushingoid (obesity and weakening of the muscles)
Dexamethasone suppression test positive

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Hyperkalaemia (damage to or disease of the kidney)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Decreased activity
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

50-59:

Anxiety
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Pain
Bone density decreased
Depression
Anaemia (lack of blood)
Back pain
Gait disturbance

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dehydration (dryness resulting from the removal of water)
Dry mouth
Electrolyte imbalance
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)
Herpes simplex (herpes simplex is a common viral infection)
Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 18.00%
High Blood Pressure: 8 people, 16.00%
Type 2 Diabetes: 7 people, 14.00%
Depression: 7 people, 14.00%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 12.00%
Blood Insulin Abnormal: 5 people, 10.00%
Diarrhea: 5 people, 10.00%
Erection Problems: 5 people, 10.00%
Gastritis (inflammation of stomach): 5 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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