Opdivo and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opdivo (nivolumab) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include cyst among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Opdivo and Adderall. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13 people who take Opdivo and Adderall together, and have interactions are studied.

What are the common drug interactions of Opdivo and Adderall, by gender? *:

female:

Cyst (a closed sac)
Electrolyte imbalance
Eyelid ptosis (falling of the upper or lower eyelid)
Fall
Fibrin d dimer increased
Headache (pain in head)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Neck mass (mass in neck)
Pleural effusion (water on the lungs)

male:

Death

What are the common drug interactions of Opdivo and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dizziness
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)

30-39:

n/a

40-49:

n/a

50-59:

Cyst (a closed sac)
Fatigue (feeling of tiredness)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Vomiting
Death

60+:

Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Neck mass (mass in neck)
Pleural effusion (water on the lungs)
Syncope (loss of consciousness with an inability to maintain postural tone)
Troponin increased
Depressed level of consciousness
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 3 people, 23.08%
Mesothelioma (rare type of cancer that occurs in the thin layer of cells lining the body's internal organs, known as the mesothelium): 3 people, 23.08%
Small Cell Carcinoma (small cell cancer tumour): 2 people, 15.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 15.38%
Thyroiditis (inflammation of thyroid gland): 1 person, 7.69%
Menstruation Delayed (late menstruation cycle): 1 person, 7.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.69%
Constipation: 1 person, 7.69%
Dizziness: 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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