Hycodan and Pemetrexed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Pemetrexed (pemetrexed). Common drug interactions include pleural effusion among females and lymphangiosis carcinomatosa among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Pemetrexed. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

14 people who take Hycodan and Pemetrexed together, and have interactions are studied.

Hycodan and Pemetrexed drug interactions.

What are the common drug interactions of Hycodan and Pemetrexed, by gender? *:

female:

Pleural effusion (water on the lungs)
Arthralgia (joint pain)
Blood iron decreased
Bone pain
Dysphagia (a condition in which swallowing is difficult or painful)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Febrile neutropenia (fever with reduced white blood cells)
Fungal infection
Infection
Neoplasm progression (growth of tumour)

male:

Lymphangiosis carcinomatosa (inflammation of the lymph vessels can lead to cancer)
Respiratory failure (inadequate gas exchange by the respiratory system)
Constipation
Dehydration (dryness resulting from the removal of water)
Duodenal ulcer
Gastric ulcer (stomach ulcer)
Haemoglobin decreased
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Intestinal ulcer
Oedema peripheral (superficial swelling)

What are the common drug interactions of Hycodan and Pemetrexed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Febrile neutropenia (fever with reduced white blood cells)

40-49:

Arthralgia (joint pain)
Blood iron decreased
Bone pain
Dysphagia (a condition in which swallowing is difficult or painful)
Fungal infection
Infection
Neoplasm progression (growth of tumour)
Non-small cell lung cancer metastatic (type of epithelial lung cancer spreads to other parts)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Oesophageal fistula (a birth defect, with the trachea connected to the oesophagus)

50-59:

Pleural effusion (water on the lungs)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

60+:

Lymphangiosis carcinomatosa (inflammation of the lymph vessels can lead to cancer)
Respiratory failure (inadequate gas exchange by the respiratory system)
Constipation
Dehydration (dryness resulting from the removal of water)
Duodenal ulcer
Gastric ulcer (stomach ulcer)
Haemoglobin decreased
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Intestinal ulcer
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 10 people, 71.43%
High Blood Pressure: 5 people, 35.71%
Nausea (feeling of having an urge to vomit): 5 people, 35.71%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 3 people, 21.43%
Constipation: 3 people, 21.43%
Prostate Cancer: 3 people, 21.43%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 3 people, 21.43%
High Blood Cholesterol: 3 people, 21.43%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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