Suboxone and Duragesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Duragesic (fentanyl). Common drug interactions include rotator cuff syndrome among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Duragesic. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,250 Suboxone users. Check the latest studies of Suboxone.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

47 people who take Suboxone and Duragesic together, and have interactions are studied.

Suboxone and Duragesic drug interactions.

What are the common drug interactions of Suboxone and Duragesic, by gender? *:

female:

Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Vomiting
Death
Drug dependence
Glaucoma (increased fluid pressure in the eye with vision loss)
Peripheral swelling
Psychotic disorder
Anxiety
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Dependence

male:

Pain
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Overdose
Depression
Substance abuse

What are the common drug interactions of Suboxone and Duragesic, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)

2-9:

n/a

10-19:

n/a

20-29:

Affect lability (emotional incontinence)
Affective disorder (mental disorder)
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Alcohol abuse
Anger
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Depression
Drug dependence

30-39:

Asthenia (weakness)
Dizziness
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Overdose
Slow speech

40-49:

Blood cholesterol increased
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Hypertension (high blood pressure)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pain
Therapeutic response decreased (less preventive response)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Weight increased
Renal failure (kidney dysfunction)

50-59:

Anxiety
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture
Bone pain
Completed suicide (act of taking one's own life)
Depression
Diarrhoea
Disturbance in attention
Drug dependence

60+:

Weight increased
Fall
Influenza
Sedation
Glaucoma (increased fluid pressure in the eye with vision loss)
Peripheral swelling
Drug hypersensitivity
Ankle fracture
Brain injury
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 27.66%
Pain: 10 people, 21.28%
Apnea (temporary absence or cessation of breathing): 6 people, 12.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 10.64%
Sleep Apnea Syndrome: 4 people, 8.51%
Drug Dependence: 4 people, 8.51%
Drowsiness: 4 people, 8.51%
Stress And Anxiety: 3 people, 6.38%
Sleep Disorder: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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