Otezla and Exforge drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Exforge (amlodipine besylate; valsartan). Common drug interactions include sepsis among females and psoriasis among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Exforge. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

32 people who take Otezla and Exforge together, and have interactions are studied.

What are the common drug interactions of Otezla and Exforge, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Abdominal discomfort
Arthralgia (joint pain)
Asthenia (weakness)
Depression
Drug eruption (adverse drug reaction of the skin)
Drug ineffective
Muscle spasms (muscle contraction)
Pain

male:

Psoriasis (immune-mediated disease that affects the skin)
Abdominal pain upper
Headache (pain in head)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Nausea (feeling of having an urge to vomit)
Rash

What are the common drug interactions of Otezla and Exforge, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Psoriasis (immune-mediated disease that affects the skin)
Abdominal discomfort
Depression
Diarrhoea
Drug ineffective
Muscle spasms (muscle contraction)
Pain
Gastric infection (infection of stomach)
Hepatic fibrosis (scarring process that represents the liver's response to injury)

60+:

Diarrhoea
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypoacusis (loss of hearing)
Neoplasm malignant (cancer tumour)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rash
Surgery

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 20 people, 62.50%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 14 people, 43.75%
High Blood Pressure: 5 people, 15.62%
Stress And Anxiety: 2 people, 6.25%
Joint Pain: 2 people, 6.25%
High Blood Cholesterol: 2 people, 6.25%
Diabetes: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Otezla and Exforge?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously