Hycodan and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Wellbutrin (bupropion hydrochloride). Common drug interactions include oedema peripheral among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Wellbutrin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

21 people who take Hycodan and Wellbutrin together, and have interactions are studied.

Hycodan and Wellbutrin drug interactions.

What are the common drug interactions of Hycodan and Wellbutrin, by gender? *:

female:

Oedema peripheral (superficial swelling)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pleural effusion (water on the lungs)
Rib fracture
Sinusitis (inflammation of sinus)
Activated partial thromboplastin time prolonged
Adjustment disorder
Blood iron decreased
Blood magnesium decreased
Blood pressure increased

male:

Pneumonia
Cardiac failure congestive
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)
Back pain
Balanitis candida (inflammation of the glands penis by infection with candida albicans)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the common drug interactions of Hycodan and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hodgkin's disease (cancer originating from white blood cells)
Impetigo (contagious skin infection)
Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears)
Lacrimation increased
Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neuropathy peripheral (surface nerve damage)
Oral herpes (viral infection of mouth)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)

30-39:

Adjustment disorder
Brain neoplasm (tumour of brain)
Candidiasis (candidiasis or thrush is a fungal infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Dependent personality disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Dysthymic disorder (mild chronic depression disorder)
Dysuria (painful or difficult urination)

40-49:

Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Activated partial thromboplastin time prolonged
Arthralgia (joint pain)
Blood iron decreased
Bone pain
Digoxin toxicity
Dysphagia (a condition in which swallowing is difficult or painful)
Fungal infection

50-59:

Abdominal discomfort
Actinomyces test positive
Anaphylactic reaction (serious allergic reaction)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)
Back pain
Balanitis candida (inflammation of the glands penis by infection with candida albicans)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Pneumonia
Cardiac failure congestive
Hypokalaemia (low potassium)
Hypovolaemia (a decreased volume of circulating blood in the body)
Laceration (tearing of soft body tissue)
Loss of consciousness
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Syncope (loss of consciousness with an inability to maintain postural tone)
Cardiomyopathy (weakening of the heart muscle)
Disease progression

What are the existing conditions these people have? *

Oropharyngeal Pain: 7 people, 33.33%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 28.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 19.05%
Pain: 4 people, 19.05%
Immunodeficiency Common Variable: 3 people, 14.29%
Insomnia (sleeplessness): 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
Constipation: 2 people, 9.52%
Fever: 2 people, 9.52%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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