Hydramine and Delsym drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Delsym (dextromethorphan polistirex). Common drug interactions include adverse drug reaction among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Delsym. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Delsym?

Delsym has active ingredients of dextromethorphan polistirex. It is often used in cough. eHealthMe is studying from 5,033 Delsym users. Check the latest studies of Delsym.

On Jul, 13, 2026

90 people who take Hydramine and Delsym together, and have interactions are studied.

What are the common drug interactions of Hydramine and Delsym, by gender? *:

female:

Adverse drug reaction
Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Breast cancer
Cell death
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Erythema (redness of the skin)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Herpes zoster

male:

Fatigue (feeling of tiredness)
Diarrhoea
Gastrointestinal toxicity (damage to digestive tract by any substance)
Haematocrit decreased
Malignant neoplasm progression (cancer tumour came back)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Metastases to lymph nodes (cancer spreads to lymph node)
Non-small cell lung cancer (type of epithelial lung cancer)
Pneumonia

What are the common drug interactions of Hydramine and Delsym, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Erythema (redness of the skin)

10-19:

n/a

20-29:

Pneumonia
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Infection
Oedema peripheral (superficial swelling)
Pain
Pain in extremity
Pyrexia (fever)
Swollen tongue (swelling of tongue)
Cellulitis (infection under the skin)
Furuncle (infection of the hair follicle)

30-39:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Confusional state
Fatigue (feeling of tiredness)
Fear
Stress

40-49:

Pneumonia
Adverse drug reaction
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fatigue (feeling of tiredness)
Infusion site bruising
Infusion site pain
Post procedural discharge
Sinusitis (inflammation of sinus)
Constipation

50-59:

Nasopharyngitis (inflammation of the nasopharynx)
Pruritus (severe itching of the skin)
Throat tightness
Pneumonia
Fatigue (feeling of tiredness)
Drug hypersensitivity
Fungal infection
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Respiratory tract infection

60+:

Infusion related reaction
Urinary tract infection
Pain
Seasonal allergy (allergic condition due to certain season)
Tooth fracture
Viral infection
Contusion (a type of hematoma of tissue in which capillaries)
Drug hypersensitivity
Eye infection
Road traffic accident

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 27 people, 30.00%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 11 people, 12.22%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 9 people, 10.00%
Asthma: 8 people, 8.89%
Pain: 6 people, 6.67%
High Blood Cholesterol: 6 people, 6.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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