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Glucophage and Bipolar disorder - a phase IV clinical study of FDA data

Summary:

Bipolar disorder is reported as a side effect among people who take Glucophage (metformin hydrochloride), especially for people who are female, 40-49 old, also take Seroquel, and have Depression.

The phase IV clinical study analyzes which people have Bipolar disorder when taking Glucophage. It is created by eHealthMe based on reports of 59,839 people who have side effects when taking Glucophage from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Bipolar disorder?

Bipolar disorder (mood disorder) is found to be associated with 913 drugs and 1,231 conditions by eHealthMe. Check the latest studies of Bipolar disorder.

On Jul, 13, 2026

59,839 people reported to have side effects when taking Glucophage.
Among them, 70 people (0.12%) have Bipolar disorder.

Could Glucophage cause Bipolar disorder?

Among these 70 people:

What is the gender of people who have Bipolar disorder when taking Glucophage? *

  • female: 55.07 %
  • male: 44.93 %

What is the age of people who have Bipolar disorder when taking Glucophage? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 6.67 %
  • 30-39: 13.33 %
  • 40-49: 36.67 %
  • 50-59: 25.0 %
  • 60+: 18.33 %

What are other drugs people take besides Glucophage? *

  1. Seroquel: 27 people, 38.57%
  2. Zyprexa: 24 people, 34.29%
  3. Albuterol: 21 people, 30.00%
  4. Valium: 20 people, 28.57%
  5. Lantus: 19 people, 27.14%
  6. Paxil: 16 people, 22.86%
  7. Humalog: 14 people, 20.00%
  8. Lasix: 14 people, 20.00%
  9. Prozac: 14 people, 20.00%
  10. Lisinopril: 14 people, 20.00%

What are other side effects people have besides Bipolar disorder? *

  1. Depression: 30 people, 42.86%
  2. Stress And Anxiety: 26 people, 37.14%
  3. Back Pain: 21 people, 30.00%
  4. Pain: 20 people, 28.57%
  5. Chest Pain: 19 people, 27.14%
  6. Abdominal Pain: 18 people, 25.71%
  7. Anhedonia (inability to experience pleasure from activities usually found enjoyable): 17 people, 24.29%
  8. Injury: 17 people, 24.29%
  9. Constipation: 16 people, 22.86%
  10. Sleep Apnea Syndrome: 15 people, 21.43%

What are the existing conditions these people have? *

  1. Depression: 15 people, 21.43%
  2. Metastases To Bone (cancer spreads to bone): 9 people, 12.86%
  3. Pain: 8 people, 11.43%
  4. Heart Rate Irregular: 7 people, 10.00%
  5. Stress And Anxiety: 6 people, 8.57%
  6. Sleep Disorder: 6 people, 8.57%
  7. Prostate Cancer: 6 people, 8.57%
  8. Nausea (feeling of having an urge to vomit): 5 people, 7.14%
  9. Insomnia (sleeplessness): 5 people, 7.14%
  10. Quit Smoking: 5 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Bipolar disorder?

- Check whether Bipolar disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage:

Bipolar disorder treatments and more:

How severe was Bipolar disorder and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar disorder:

Browse all the conditions that are associated with Bipolar disorder:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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