Hydrea and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Ambien (zolpidem tartrate). Common drug interactions include dyspnoea exertional among females and platelet count increased among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Ambien. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

On Jul, 15, 2026

94 people who take Hydrea and Ambien together, and have interactions are studied.

What are the common drug interactions of Hydrea and Ambien, by gender? *:

female:

Dyspnoea exertional (breathlessness or shortness of breath)
Non-cardiac chest pain
Splenic rupture
Abdominal distension
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Acute respiratory distress syndrome
Allergy to chemicals
Aseptic necrosis bone
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased

male:

Platelet count increased
Death
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood creatinine increased
Blood glucose increased
Blood urea increased
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Hydrea and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pain
Dyspnoea exertional (breathlessness or shortness of breath)
Non-cardiac chest pain
Cellulitis (infection under the skin)
Death
Haematocrit decreased
Haemoglobin decreased
Nausea (feeling of having an urge to vomit)
Rash
Red blood cell count decreased

30-39:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Enterococcal infection
Neoplasm progression (growth of tumour)
Oedema peripheral (superficial swelling)
Pain in extremity
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

40-49:

Hip arthroplasty
Injection site pain
Osteonecrosis (death of bone)

50-59:

Stomatitis (inflammation of mucous membrane of mouth)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Arthralgia (joint pain)
Back pain
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Chest pain
Clostridial infection (infectious conditions by clostridium bacteria)
Colitis (inflammation of colon)
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)

60+:

Fatigue (feeling of tiredness)
Haemoglobin decreased
Dry skin
Fall
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Rash
Back pain
Blood potassium increased
Chest injury
Diarrhoea

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 16 people, 17.02%
Primary Myelofibrosis (primary disorder of the bone marrow): 15 people, 15.96%
Stress And Anxiety: 13 people, 13.83%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 12.77%
Depression: 12 people, 12.77%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 12 people, 12.77%
Pain: 9 people, 9.57%
High Blood Pressure: 8 people, 8.51%
Nausea (feeling of having an urge to vomit): 7 people, 7.45%
Essential Thrombocythaemia (chronic blood cancer): 7 people, 7.45%

* Approximation only. Some reports may have incomplete information.

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