Hydrea and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Keppra (levetiracetam). Common drug interactions include palmar-plantar erythrodysaesthesia syndrome among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Keppra. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 09, 2026

45 people who take Hydrea and Keppra together, and have interactions are studied.

What are the common drug interactions of Hydrea and Keppra, by gender? *:

female:

Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
Pregnancy
Rash
Thrombocytosis
Thyroid disorder (thyroid diseases)
Upper limb fracture
Urinary tract infection
Vomiting

male:

Asthenia (weakness)
Cerebral haemorrhage (bleeding within the brain)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Anxiety
Fatigue (feeling of tiredness)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Hydrea and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Weight increased

10-19:

n/a

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug ineffective
Drug level below therapeutic
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypertension (high blood pressure)
International normalised ratio increased
Streptococcal bacteraemia (a bacterial infection of blood)

30-39:

Back pain
Limb discomfort (discomfort in leg)
Pain in extremity
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

40-49:

Myeloid leukaemia (a type of cancer in which the bone marrow makes abnormal myeloblasts)
Sinusitis (inflammation of sinus)

50-59:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Respiratory failure (inadequate gas exchange by the respiratory system)
Fatigue (feeling of tiredness)
Anticonvulsant drug level below therapeutic
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Blood creatinine increased
Confusional state
Diarrhoea
Dizziness

60+:

Cerebral haemorrhage (bleeding within the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Hallucination (an experience involving the perception of something not present)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Creatinine renal clearance decreased
Death
Failure to thrive (inadequate weight gain and physical growth in children)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Neurological decompensation (inability of brain to maintain proper function)
Neutropenia (an abnormally low number of neutrophils)

What are the existing conditions these people have? *

Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 8 people, 17.78%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 15.56%
High Blood Pressure: 6 people, 13.33%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 11.11%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 8.89%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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