Hydrea and Vesicare drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Vesicare (solifenacin succinate). Common drug interactions include bone marrow failure among females and dry mouth among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Vesicare. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,655 Vesicare users. Check the latest studies of Vesicare.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

18 people who take Hydrea and Vesicare together, and have interactions are studied.

What are the common drug interactions of Hydrea and Vesicare, by gender? *:

female:

Bone marrow failure
Febrile neutropenia (fever with reduced white blood cells)
Lymphocyte count increased
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Natural killer cell count increased (natural killer cell number increased)
Death
Infection
Myelosuppression (a decrease in the production of blood cells)
Blood lactate dehydrogenase increased
Pyrexia (fever)

male:

Dry mouth
Dysgeusia (disorder of the sense of taste)
Polydipsia (excessive thirst)
Polyuria (production of too much dilute urine)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite
Insomnia (sleeplessness)
Weight decreased

What are the common drug interactions of Hydrea and Vesicare, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Blood lactate dehydrogenase increased
Pyrexia (fever)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death
Decreased appetite
Infection
Insomnia (sleeplessness)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Myelosuppression (a decrease in the production of blood cells)
Weight decreased

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 9 people, 50.00%
High Blood Pressure: 8 people, 44.44%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 7 people, 38.89%
Neuralgia (pain in one or more nerves): 7 people, 38.89%
Menopausal Symptoms: 7 people, 38.89%
Locked-In Syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis): 7 people, 38.89%
Itching: 7 people, 38.89%
Constipation: 7 people, 38.89%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 16.67%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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