Hydrocodone and Progesterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Progesterone (progesterone). Common drug interactions include nasopharyngitis among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Progesterone. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,022 Progesterone users. Check the latest studies of Progesterone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

64 people who take Hydrocodone and Progesterone together, and have interactions are studied.

Hydrocodone and Progesterone drug interactions.

What are the common drug interactions of Hydrocodone and Progesterone, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Anxiety
Diarrhoea
Fall
Injection site pruritus (severe itching at injection site)
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)
Abdominal discomfort
Back pain
Drug ineffective

male:

Anaemia (lack of blood)
Arthralgia (joint pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Thrombocytopenia (decrease of platelets in blood)
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Infection

What are the common drug interactions of Hydrocodone and Progesterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site reaction
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injection site bruising
Injection site pain
Injection site rash
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nasopharyngitis (inflammation of the nasopharynx)
Post-traumatic stress disorder
Sedation
Sinusitis (inflammation of sinus)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lung disorder (lung disease)

50-59:

Chronic kidney disease
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Colonoscopy
Fatigue (feeling of tiredness)
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Muscle atrophy (a decrease in the mass of the muscle)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)

60+:

Fall
Limb injury
Back injury
Back pain
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Depression
Diarrhoea
Disability
Disturbance in attention
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 25 people, 39.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 22 people, 34.38%
Immunodeficiency Common Variable: 9 people, 14.06%
Stress And Anxiety: 8 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 12.50%
Insomnia (sleeplessness): 7 people, 10.94%
High Blood Cholesterol: 7 people, 10.94%
Pain: 6 people, 9.38%
High Blood Pressure: 6 people, 9.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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