Hydrocodone and Sustiva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Sustiva (efavirenz). Common drug interactions include death among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Sustiva. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Sustiva?

Sustiva has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 11,040 Sustiva users. Check the latest studies of Sustiva.

On Jul, 12, 2026

70 people who take Hydrocodone and Sustiva together, and have interactions are studied.

Hydrocodone and Sustiva drug interactions.

What are the common drug interactions of Hydrocodone and Sustiva, by gender? *:

female:

Death
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Gait disturbance
Quality of life decreased
Renal injury (kidney injury)
Abnormal dreams
Asthenia (weakness)
Blood creatinine increased
Decreased appetite

male:

Anxiety
Emotional distress
Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Renal failure (kidney dysfunction)
Back pain
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)
Hypertension (high blood pressure)
Dysstasia (difficulty in standing)

What are the common drug interactions of Hydrocodone and Sustiva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Asthenia (weakness)
Back pain
Dysstasia (difficulty in standing)
Emotional distress
Exercise tolerance decreased
Fatigue (feeling of tiredness)

40-49:

Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Depression
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Fatigue (feeling of tiredness)
Foot fracture
Gait disturbance
Anaemia (lack of blood)
Blood creatinine increased
Bone pain

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Gait disturbance
Anaemia (lack of blood)
Bone density decreased
Depression

60+:

Emotional distress
Pain
Bone disorder
Cervical vertebral fracture
Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Erectile dysfunction
Gout (uric acid crystals building up in the body)
Hypertension (high blood pressure)
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Hiv Infection: 67 people, 95.71%
Pain: 12 people, 17.14%
Bacterial Infection: 11 people, 15.71%
Stress And Anxiety: 9 people, 12.86%
Depression: 8 people, 11.43%
High Blood Pressure: 7 people, 10.00%
High Blood Cholesterol: 7 people, 10.00%
Fungal Infection: 6 people, 8.57%
Osteoporosis (bones weak and more likely to break): 5 people, 7.14%
Hypersensitivity: 5 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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