Hydrocortisone and Ampyra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortisone (hydrocortisone) and Ampyra (dalfampridine). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortisone and Ampyra. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

What is Ampyra?

Ampyra has active ingredients of dalfampridine. It is often used in multiple sclerosis. eHealthMe is studying from 77,145 Ampyra users. Check the latest studies of Ampyra.

On Aug, 02, 2026

33 people who take Hydrocortisone and Ampyra together, and have interactions are studied.

Hydrocortisone and Ampyra drug interactions.

What are the common drug interactions of Hydrocortisone and Ampyra, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Oxygen saturation decreased
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)

male:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Wound
Therapeutic response unexpected
Malaise (a feeling of general discomfort or uneasiness)
Dysgraphia (impaired ability to learn to write)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Agnosia (inability to interpret sensations and hence to recognize things, typically as a result of brain damage)

What are the common drug interactions of Hydrocortisone and Ampyra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure increased
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Glucose tolerance impaired in pregnancy (higher glucose level in pregnancy but not diabetes)
Headache (pain in head)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Premature labour
Swelling

40-49:

n/a

50-59:

General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Therapeutic response unexpected
Pulmonary embolism (blockage of the main artery of the lung)
Asthenia (weakness)
Influenza like illness
Injection site erythema (redness at injection site)
Injection site mass
Injection site pruritus (severe itching at injection site)

60+:

Diarrhoea
Hypotension (abnormally low blood pressure)
Anaemia (lack of blood)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bacterial test positive
Blood albumin decreased
Blood calcium decreased
Blood creatinine increased
Blood glucose increased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 27.27%
Gait Disturbance: 5 people, 15.15%
Combined Immunodeficiency: 4 people, 12.12%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.09%
Pain: 3 people, 9.09%
Adrenoleukodystrophy (loss of myelin surrounding nerve cells in the brain and progressive adrenal gland): 3 people, 9.09%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.06%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 6.06%
Iron Deficiency: 2 people, 6.06%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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