Hydrocortisone and Locoid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortisone (hydrocortisone) and Locoid (hydrocortisone butyrate). Common drug interactions include dry skin among females and conjunctivitis among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortisone and Locoid. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,426 Hydrocortisone users. Check the latest studies of Hydrocortisone.

What is Locoid?

Locoid has active ingredients of hydrocortisone butyrate. eHealthMe is studying from 1,996 Locoid users. Check the latest studies of Locoid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

18 people who take Hydrocortisone and Locoid together, and have interactions are studied.

Hydrocortisone and Locoid drug interactions.

What are the common drug interactions of Hydrocortisone and Locoid, by gender? *:

female:

Dry skin
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Pain of skin
Pancreatitis (inflammation of pancreas)
Rash pruritic (redness with itching)
Skin burning sensation
Skin fissures (a crack in the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Deformity (disfigurement)

male:

Conjunctivitis (pink eye)
Suicidal ideation
Visual impairment
Erythema (redness of the skin)
Feeling hot
Pruritus (severe itching of the skin)
Rash
Application site bleeding
Application site erythema (redness of the skin at application site)
Application site pain

What are the common drug interactions of Hydrocortisone and Locoid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pain
Skin infection
Skin reaction

10-19:

Erythema (redness of the skin)
Feeling hot
Pain
Pruritus (severe itching of the skin)
Rash
Skin infection
Skin reaction

20-29:

Pancreatitis (inflammation of pancreas)

30-39:

Deformity (disfigurement)
Dry skin
Excoriation (to tear or wear off the skin of)
Generalised erythema (redness of the skin all over the body)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Pain
Pain in extremity

40-49:

n/a

50-59:

n/a

60+:

Dry skin
Pruritus (severe itching of the skin)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oral herpes (viral infection of mouth)
Rash
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rash pruritic (redness with itching)
Skin burning sensation
Skin fissures (a crack in the skin)
Skin swelling

What are the existing conditions these people have? *

Rashes (redness): 5 people, 27.78%
Itching: 5 people, 27.78%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 27.78%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 22.22%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 4 people, 22.22%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 22.22%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 4 people, 22.22%
Mood Swings (an extreme or rapid change in mood): 4 people, 22.22%
Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 4 people, 22.22%
Depressed Mood: 4 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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