Hydrocortone and Polaramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortone (hydrocortisone acetate) and Polaramine (dexchlorpheniramine maleate). Common drug interactions include chronic lymphocytic leukaemia among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortone and Polaramine. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortone?

Hydrocortone has active ingredients of hydrocortisone acetate. It is often used in pain. eHealthMe is studying from 912 Hydrocortone users. Check the latest studies of Hydrocortone.

What is Polaramine?

Polaramine has active ingredients of dexchlorpheniramine maleate. It is often used in allergic rhinitis. eHealthMe is studying from 10,531 Polaramine users. Check the latest studies of Polaramine.

On Jul, 17, 2026

21 people who take Hydrocortone and Polaramine together, and have interactions are studied.

Hydrocortone and Polaramine drug interactions.

What are the common drug interactions of Hydrocortone and Polaramine, by gender? *:

female:

Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Drug ineffective
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Venoocclusive disease (small veins in the liver are obstructed)
Aortitis (inflammation of the aortic wall)
Arteritis (inflammation of the walls of arteries)

male:

Pneumonia
Pyrexia (fever)
Platelet count decreased
Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Constipation
Depressed level of consciousness
Fibrin d dimer increased
Hyperuricaemia (level of uric acid in the blood that is abnormally high)

What are the common drug interactions of Hydrocortone and Polaramine, by age (0-1 to 60+)? *:

0-1:

Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Drug ineffective
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Venoocclusive disease (small veins in the liver are obstructed)

2-9:

n/a

10-19:

n/a

20-29:

Febrile neutropenia (fever with reduced white blood cells)
Headache (pain in head)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Oxygen saturation decreased
Platelet count decreased
Pyrexia (fever)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Vomiting
White blood cell count decreased

30-39:

Systemic candida (whole body fungal infection)

40-49:

n/a

50-59:

Diarrhoea
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Febrile neutropenia (fever with reduced white blood cells)
Fibrin d dimer increased
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypokalaemia (low potassium)
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Ventricular extrasystoles (premature cardiac contraction)

60+:

Pneumonia
Pyrexia (fever)
Anaemia (lack of blood)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Fibrin degradation products increased
Hyperglycaemia (high blood sugar)
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Weight increased
Aortitis (inflammation of the aortic wall)

What are the existing conditions these people have? *

Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 6 people, 28.57%
Allergies: 5 people, 23.81%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 3 people, 14.29%
Pleural Effusion (water on the lungs): 2 people, 9.52%
Microscopic Polyangiitis (inflammation involving multiple blood or lymph small-vessel): 2 people, 9.52%
Hyperglycemia (high blood sugar): 2 people, 9.52%
Fibrin Degradation Products Increased: 2 people, 9.52%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 9.52%
Engraftment Syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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