Hydromorphone hydrochloride and Naloxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydromorphone hydrochloride (hydromorphone hydrochloride) and Naloxone (naloxone hydrochloride). Common drug interactions include rhinorrhoea among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Hydromorphone hydrochloride and Naloxone. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Hydromorphone hydrochloride?

Hydromorphone hydrochloride has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 13,898 Hydromorphone hydrochloride users. Check the latest studies of Hydromorphone hydrochloride.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

On Aug, 02, 2026

72 people who take Hydromorphone hydrochloride and Naloxone together, and have interactions are studied.

Hydromorphone hydrochloride and Naloxone drug interactions.

What are the common drug interactions of Hydromorphone Hydrochloride and Naloxone, by gender? *:

female:

Rhinorrhoea (watery mucus discharge from the nose)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Drug abuse
Blood pressure increased
Respiratory depression (respiration has a rate below 12 breaths)
Respiratory rate decreased (less breathing rate/min)
Unresponsive to stimuli
Diarrhoea
Abdominal pain

male:

Hypotension (abnormally low blood pressure)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Osteoporosis (bones weak and more likely to break)
Overdose
Rash
Abdominal discomfort
Abdominal distension
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenia (weakness)

What are the common drug interactions of Hydromorphone Hydrochloride and Naloxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Aplasia (defective development or congenital absence of an organ or tissue)
Chills (felling of cold)
Febrile neutropenia (fever with reduced white blood cells)

10-19:

Abdominal pain lower
Abdominal pain upper
Abdominal tenderness
Chills (felling of cold)
Cholecystitis chronic (long lasting infection of gallbladder)
Decreased appetite
Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting
Lung neoplasm (tumour of lung)

20-29:

Death
Erythema (redness of the skin)
Febrile neutropenia (fever with reduced white blood cells)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Lip swelling
Respiration (transport of oxygen from the outside air to the cells within tissues)

30-39:

Maternal exposure during pregnancy (use of substance during pregnancy)
Overdose
Drug dependence
Hyperhidrosis (abnormally increased sweating)
Maternal exposure during delivery (use of substance during pregnancy)
Restlessness (not able to rest)
Rhinorrhoea (watery mucus discharge from the nose)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Drug abuse

40-49:

Anaemia (lack of blood)
Cardiac failure congestive
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Hyperglycaemia (high blood sugar)
Hypoxia (low oxygen in tissues)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Headache (pain in head)

50-59:

Photocoagulation
Pneumonia bacterial (pneumonia associated with bacterial infection)
Polyp
Rash
Renal failure (kidney dysfunction)
Retinal degeneration (death of the cells of the retina)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Retinal haemorrhage (bleeding from retina)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sinusitis (inflammation of sinus)

60+:

Hypotension (abnormally low blood pressure)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Abdominal pain
Accident at work
Acute myocardial infarction (acute heart attack)
Acute sinusitis
Angina pectoris (chest pain due to ischemia of the heart muscle)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Arthralgia (joint pain)
Blood calcium decreased

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 11.11%
Staphylococcal Bacteraemia (a bacterial infection of blood): 5 people, 6.94%
Pyomyositis (acute bacterial infection of skeletal muscle): 5 people, 6.94%
High Blood Pressure: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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