Hydroxocobalamin and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxocobalamin (hydroxocobalamin) and Methotrexate sodium (methotrexate sodium). Common drug interactions include pancytopenia among females and biliary sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxocobalamin and Methotrexate sodium. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxocobalamin?

Hydroxocobalamin has active ingredients of hydroxocobalamin. It is often used in pernicious anaemia. eHealthMe is studying from 4,273 Hydroxocobalamin users. Check the latest studies of Hydroxocobalamin.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

On Jul, 19, 2026

16 people who take Hydroxocobalamin and Methotrexate sodium together, and have interactions are studied.

Hydroxocobalamin and Methotrexate sodium drug interactions.

What are the common drug interactions of Hydroxocobalamin and Methotrexate Sodium, by gender? *:

female:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure (kidney dysfunction)
Weight decreased
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Adverse event
Alveolitis (inflammation in the socket of a tooth)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Cytomegalovirus infection
Diabetic foot
Dizziness

male:

Biliary sepsis
Cellulitis (infection under the skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pancreatitis acute (sudden inflammation of pancreas)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Rectal haemorrhage (bleeding from anus)
Chills (felling of cold)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

What are the common drug interactions of Hydroxocobalamin and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Adverse event
Diabetic foot
Migraine (headache)
Neuropathy peripheral (surface nerve damage)
Postoperative wound infection
Uterine disorder
Weight decreased

50-59:

Biliary sepsis
Cellulitis (infection under the skin)
Chills (felling of cold)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Vomiting
Localised infection (infection at the single location)
Asthma
Dyspnoea (difficult or laboured respiration)

60+:

Renal failure (kidney dysfunction)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Lower respiratory tract infection
Mouth ulceration (mouth ulcers)
Nausea (feeling of having an urge to vomit)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Overdose
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peripheral swelling
Pneumonia

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 25.00%
Wound Infection: 3 people, 18.75%
Vitamin B12 Deficiency: 3 people, 18.75%
Sleep Disorder: 1 person, 6.25%
Pain: 1 person, 6.25%
Erection Problems: 1 person, 6.25%
Dyslipidaemia (abnormal amount of lipids): 1 person, 6.25%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 1 person, 6.25%
Depression: 1 person, 6.25%
Breast Cancer: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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