Hydroxocobalamin and Trimethoprim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxocobalamin (hydroxocobalamin) and Trimethoprim (trimethoprim). Common drug interactions include neutropenic sepsis among females and aphthous stomatitis among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxocobalamin and Trimethoprim. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxocobalamin?

Hydroxocobalamin has active ingredients of hydroxocobalamin. It is often used in pernicious anaemia. eHealthMe is studying from 4,273 Hydroxocobalamin users. Check the latest studies of Hydroxocobalamin.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

85 people who take Hydroxocobalamin and Trimethoprim together, and have interactions are studied.

Hydroxocobalamin and Trimethoprim drug interactions.

What are the common drug interactions of Hydroxocobalamin and Trimethoprim, by gender? *:

female:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Contusion (a type of hematoma of tissue in which capillaries)
Somnolence (a state of near-sleep, a strong desire for sleep)
Coma (state of unconsciousness lasting more than six hours)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Arthralgia (joint pain)
Rash
Bone pain

male:

Aphthous stomatitis (mouth ulcer)
Myalgia (muscle pain)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fatigue (feeling of tiredness)
Haematuria (presence of blood in urine)
Haemorrhage (bleeding)
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Ischaemic cerebral infarction (ischemic stroke resulting from a disturbance in the blood vessels supplying blood to the brain)

What are the common drug interactions of Hydroxocobalamin and Trimethoprim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
C-reactive protein increased
Cancer pain
Diarrhoea
Mucosal inflammation (infection of mucous membrane)
Oedema peripheral (superficial swelling)
Vomiting
Wound
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Dry Skin: 24 people, 28.24%
Wound: 22 people, 25.88%
Skin Ulcer: 22 people, 25.88%
Breast Cancer Metastatic: 22 people, 25.88%
Cellulitis (infection under the skin): 22 people, 25.88%
Fever: 22 people, 25.88%
Abdominal Hernia Obstructive (abdominal hernia causing a blockage): 22 people, 25.88%
Joint Pain: 22 people, 25.88%
Oedema Peripheral (superficial swelling): 22 people, 25.88%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 17 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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