Hydroxyurea and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Diflucan (fluconazole). Common drug interactions include diarrhoea among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Diflucan. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

On Jul, 26, 2026

52 people who take Hydroxyurea and Diflucan together, and have interactions are studied.

Hydroxyurea and Diflucan drug interactions.

What are the common drug interactions of Hydroxyurea and Diflucan, by gender? *:

female:

Diarrhoea
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Hot flushes (sudden feelings of heat)
Hypotension (abnormally low blood pressure)
Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Tendonitis (a condition that causes pain and swelling of tendons)

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Eye haemorrhage (bleeding in the eye)
Thrombocytopenia (decrease of platelets in blood)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Hypersensitivity
Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Abdominal discomfort
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Ascites (accumulation of fluid in the abdominal cavity)

What are the common drug interactions of Hydroxyurea and Diflucan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Digoxin toxicity
Nausea (feeling of having an urge to vomit)
Vomiting

10-19:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Hot flushes (sudden feelings of heat)
Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)
Myalgia (muscle pain)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Tendonitis (a condition that causes pain and swelling of tendons)
Acute sinusitis

40-49:

Jaundice cholestatic
Lipase increased
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Renal failure (kidney dysfunction)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Amoebic liver abscess (a amoebic liver abscess is a type of liver abscess caused by amebiasis)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Arterial rupture
Arthralgia (joint pain)

50-59:

Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Diarrhoea
Fall
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Atelectasis (partial or complete collapse of the lung)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Thrombocytopenia (decrease of platelets in blood)
Infusion related reaction
Malignant neoplasm progression (cancer tumour came back)
Melaena (the passage of black, tarry stools)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Back pain
Balance disorder
Blood calcium decreased
Blood creatinine increased

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 12 people, 23.08%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 7.69%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 7.69%
Stress And Anxiety: 3 people, 5.77%
Nausea (feeling of having an urge to vomit): 3 people, 5.77%
Leukocytosis (increased white blood cells): 3 people, 5.77%
High Blood Pressure: 3 people, 5.77%
Fluid Overload (too much fluid in the blood): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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