Hydroxyurea and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include neutropenia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

On Jul, 10, 2026

44 people who take Hydroxyurea and Valacyclovir hydrochloride together, and have interactions are studied.

Hydroxyurea and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Hydroxyurea and Valacyclovir Hydrochloride, by gender? *:

female:

Neutropenia (an abnormally low number of neutrophils)
Escherichia sepsis (bacterial infection by escherichia coli)
Septic shock (shock due to blood infection)
Decreased appetite
Febrile neutropenia (fever with reduced white blood cells)
Weight decreased
C-reactive protein increased
Device related infection
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)

male:

Febrile neutropenia (fever with reduced white blood cells)
Death
Mucosal inflammation (infection of mucous membrane)
Pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Haemorrhage intracranial (bleeding within the skull)
Pneumonia
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

What are the common drug interactions of Hydroxyurea and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)

10-19:

Abdominal pain
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Insomnia (sleeplessness)
Mucosal inflammation (infection of mucous membrane)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)

20-29:

Arrhythmia (irregular heartbeat)
Death

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Extremity necrosis (death of body tissue of arms and legs)
Jugular vein thrombosis (clot in jugular vein)
Weight increased

40-49:

Febrile neutropenia (fever with reduced white blood cells)
Haemorrhage intracranial (bleeding within the skull)
Pneumonia
Acute respiratory distress syndrome
Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Chronic kidney disease

50-59:

n/a

60+:

Neutropenia (an abnormally low number of neutrophils)
Escherichia sepsis (bacterial infection by escherichia coli)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)
Vomiting
White blood cell count increased
Enterococcal infection

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 20 people, 45.45%
High Blood Pressure: 6 people, 13.64%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 5 people, 11.36%
Folate Deficiency (lack of folic acid): 4 people, 9.09%
Fever: 4 people, 9.09%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 6.82%
Joint Swelling: 3 people, 6.82%
Acute Myeloid Leukaemia Recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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