Hydroxyurea and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include drug resistance among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Vitamin e. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

On Jul, 31, 2026

78 people who take Hydroxyurea and Vitamin e together, and have interactions are studied.

Hydroxyurea and Vitamin e drug interactions.

What are the common drug interactions of Hydroxyurea and Vitamin E, by gender? *:

female:

Drug resistance (reduction in effectiveness of a drug)
Fistula (an abnormal connection or passageway between two)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Heart rate increased
Hypertension (high blood pressure)
Malignant neoplasm progression (cancer tumour came back)
Mean cell haemoglobin decreased (less than normal haemoglobin per red blood cell in a sample of blood)
Neoplasm malignant (cancer tumour)
Nephrolithiasis (calculi in the kidneys)

male:

Alanine aminotransferase increased
Ammonia increased
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hypotrichosis (a condition that affects hair growth)
Infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pruritus (severe itching of the skin)
Pyrexia (fever)

What are the common drug interactions of Hydroxyurea and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypopnoea (decrease in the breathing rate)
Oxygen saturation decreased

20-29:

Hypoacusis (loss of hearing)
Tinnitus (a ringing in the ears)

30-39:

Pyrexia (fever)
Abdominal pain
Arteriovenous fistula
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug resistance (reduction in effectiveness of a drug)
Fistula (an abnormal connection or passageway between two)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)

40-49:

Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Implant infection (infection at implant site)
Liver fatty (fat deposition of liver)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Methicillin-resistant staphylococcal aureus infection
Nasopharyngitis (inflammation of the nasopharynx)
Pruritus (severe itching of the skin)
Splenomegaly (enlargement of spleen)

50-59:

Headache (pain in head)

60+:

Depression
Dyspnoea (difficult or laboured respiration)
Rash
Restlessness (not able to rest)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anxiety
Arrhythmia (irregular heartbeat)
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 13 people, 16.67%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 7 people, 8.97%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 6 people, 7.69%
Osteoporosis (bones weak and more likely to break): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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