Hydroxyurea and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Wellbutrin (bupropion hydrochloride). Common drug interactions include diarrhoea among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Wellbutrin. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 08, 2026

98 people who take Hydroxyurea and Wellbutrin together, and have interactions are studied.

Hydroxyurea and Wellbutrin drug interactions.

What are the common drug interactions of Hydroxyurea and Wellbutrin, by gender? *:

female:

Diarrhoea
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Emotional distress
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Haematemesis (vomiting of blood)
Hypoaesthesia (reduced sense of touch or sensation)

male:

Pain
Fatigue (feeling of tiredness)
Skin cancer
Thrombosis (formation of a blood clot inside a blood vessel)
Thyroid disorder (thyroid diseases)
Vomiting
Abdominal discomfort
Acute sinusitis
Aggression
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Hydroxyurea and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infusion related reaction
Pain

20-29:

Abdominal discomfort
Fatigue (feeling of tiredness)
Headache (pain in head)
Ill-defined disorder
Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)
Vomiting

30-39:

Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Constipation
Cystitis noninfective (non-infectious inflammation of the wall of the bladder)
Decreased appetite
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Fatigue (feeling of tiredness)
Glossitis (infection of tongue with soreness)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)

40-49:

Diarrhoea
Insomnia (sleeplessness)
Lymphadenopathy (disease or enlargement of lymph nodes)
Oral pain
Pruritus (severe itching of the skin)
Rash pruritic (redness with itching)
Weight decreased
Blood creatinine increased
Calculus urinary (stone in urinary system)
Complication of device insertion

50-59:

Hospitalisation
Pulmonary embolism (blockage of the main artery of the lung)
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

Pain in extremity
Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Emotional distress
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Injury

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 24 people, 24.49%
Primary Myelofibrosis (primary disorder of the bone marrow): 11 people, 11.22%
Pain: 11 people, 11.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 9.18%
Stress And Anxiety: 7 people, 7.14%
Nausea (feeling of having an urge to vomit): 7 people, 7.14%
Platelet Count Increased: 6 people, 6.12%
Panic Disorder: 6 people, 6.12%
Oropharyngeal Pain: 6 people, 6.12%
Muscle Aches (muscle pain): 6 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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