Hydroxyzine and Caplyta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Caplyta (lumateperone tosylate). Common drug interactions include depressive symptom among females and performance status decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Caplyta. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Caplyta?

Caplyta has active ingredients of lumateperone tosylate. eHealthMe is studying from 3,109 Caplyta users. Check the latest studies of Caplyta.

On Jul, 16, 2026

52 people who take Hydroxyzine and Caplyta together, and have interactions are studied.

Hydroxyzine and Caplyta drug interactions.

What are the common drug interactions of Hydroxyzine and Caplyta, by gender? *:

female:

Depressive symptom
Maternal exposure during pregnancy (use of substance during pregnancy)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Negative thoughts
Pain in extremity
Suicidal behaviour
Weight loss poor
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abdominal discomfort
Abdominal pain

male:

Performance status decreased
Dizziness
Slow speech
Weight increased
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Suicidal ideation
Suicide attempt
Agitation (state of anxiety or nervous excitement)
Bipolar disorder (mood disorder)
Blood pressure increased

What are the common drug interactions of Hydroxyzine and Caplyta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Chills (felling of cold)
Fear
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Lethargy (tiredness)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Panic reaction
Sleep paralysis (waking up and unable to move or speak)

20-29:

Vision blurred
Weight decreased
Performance status decreased
Headache (pain in head)
Balance disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Gait disturbance
Slow speech
Alopecia (absence of hair from areas of the body)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

30-39:

Dizziness
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Confusional state
Disturbance in attention
Nausea (feeling of having an urge to vomit)
Sedation
Weight increased

40-49:

Burning sensation
Headache (pain in head)
Abdominal discomfort
Back pain
Chest pain
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Excessive eye blinking (excessive blinking is dry eyes)
Feeling hot
Gingival disorder (gum disease)

50-59:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Somnolence (a state of near-sleep, a strong desire for sleep)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain
Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Burning sensation

60+:

Hyperhidrosis (abnormally increased sweating)
Aggression
Chills (felling of cold)
Confusional state
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Feeling hot
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 19 people, 36.54%
Depression: 7 people, 13.46%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 7.69%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 5.77%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 5.77%
Affective Disorder (mental disorder): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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