Hydroxyzine and Dayquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Dayquil (acetaminophen; dextromethorphan; pseudoephedrine). Common drug interactions include blood pressure increased among females.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Dayquil. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

On Jul, 08, 2026

11 people who take Hydroxyzine and Dayquil together, and have interactions are studied.

Hydroxyzine and Dayquil drug interactions.

What are the common drug interactions of Hydroxyzine and Dayquil, by gender? *:

female:

Blood pressure increased
Cataract (clouding of the lens inside the eye)
Nausea (feeling of having an urge to vomit)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Suicidal ideation
Upper respiratory tract infection
Urinary tract infection
Weight decreased
Extrasystoles
Breast cancer female

male:

n/a

What are the common drug interactions of Hydroxyzine and Dayquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Suicidal ideation
Headache (pain in head)
Muscle spasms (muscle contraction)
Somnambulism (sleep walking)

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Retching (strong involuntary effort to vomit)
Vulvovaginal candidiasis (vulvovaginal infection by fungi)
Weight decreased
Decreased appetite
Diarrhoea

40-49:

n/a

50-59:

n/a

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Hordeolum (small collection of pus (abscess) on the eyelid)
Infusion site pain
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Upper respiratory tract infection
Urinary tract infection
Breast cancer female

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 45.45%
Primary Immunodeficiency Syndrome: 2 people, 18.18%
Immunodeficiency Common Variable: 2 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 18.18%
White Blood Cell Disorder: 1 person, 9.09%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 1 person, 9.09%
Immunodeficiency: 1 person, 9.09%
Drowsiness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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