Hypericum perforatum and Amlodipine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hypericum perforatum (st. john's wort) and Amlodipine (amlodipine besylate). Common drug interactions include panic disorder among females and lip erosion among males.

The phase IV clinical study analyzes what interactions people have when they take Hypericum perforatum and Amlodipine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Hypericum perforatum?

Hypericum perforatum has active ingredients of st. john's wort. It is often used in depression. eHealthMe is studying from 305 Hypericum perforatum users. Check the latest studies of Hypericum perforatum.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,829 Amlodipine users. Check the latest studies of Amlodipine.

On Jul, 18, 2026

11 people who take Hypericum perforatum and Amlodipine together, and have interactions are studied.

Hypericum perforatum and Amlodipine drug interactions.

What are the common drug interactions of Hypericum Perforatum and Amlodipine, by gender? *:

female:

Panic disorder
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Pericardial effusion (fluid around the heart)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anxiety
Arrhythmia (irregular heartbeat)
Muscle spasms (muscle contraction)

male:

Lip erosion (peeling off of lip)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Skin lesion
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Genital erythema (redness of genitals)

What are the common drug interactions of Hypericum Perforatum and Amlodipine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Anxiety
Arrhythmia (irregular heartbeat)
Genital erythema (redness of genitals)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Pericardial effusion (fluid around the heart)
Sepsis (a severe blood infection that can lead to organ failure and death)
Muscle spasms (muscle contraction)
Panic disorder
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Lip erosion (peeling off of lip)

What are the existing conditions these people have? *

Asthma: 7 people, 63.64%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 6 people, 54.55%
Sleep Disorder: 2 people, 18.18%
Pain: 2 people, 18.18%
Heart Disease: 2 people, 18.18%
Electrolyte Imbalance: 2 people, 18.18%
Diabetes: 2 people, 18.18%
Constipation: 2 people, 18.18%
Anaesthesia: 2 people, 18.18%
Agitation (state of anxiety or nervous excitement): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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