Hysingla and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hysingla (hydrocodone bitartrate) and Zofran (ondansetron hydrochloride). Common drug interactions include diarrhoea among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Hysingla and Zofran. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 10, 2026

29 people who take Hysingla and Zofran together, and have interactions are studied.

What are the common drug interactions of Hysingla and Zofran, by gender? *:

female:

Diarrhoea
Intestinal obstruction
Weight decreased
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Pain
Back pain
Headache (pain in head)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Gastrointestinal fistula (an abnormal opening that allows the contents of the stomach or intestines to leak)

male:

Drug dependence
Abnormal behaviour
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Partial seizures (seizures which affect only a part of the brain at onset)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Rib fracture
Suicidal ideation
Traumatic liver injury
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Hysingla and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug abuse
Drug dependence
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Rib fracture
Traumatic liver injury

30-39:

n/a

40-49:

Abdominal pain upper
Arthralgia (joint pain)
Back pain
Balance disorder
Cataract (clouding of the lens inside the eye)
Chills (felling of cold)
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Ear infection

50-59:

Back pain
Decreased appetite
Furuncle (infection of the hair follicle)
Injection site bruising
Malaise (a feeling of general discomfort or uneasiness)

60+:

Weight decreased
Diarrhoea
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Febrile neutropenia (fever with reduced white blood cells)
Laryngitis (inflammation of the larynx)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Rash
Respiration (transport of oxygen from the outside air to the cells within tissues)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 17.24%
Multiple Myeloma (cancer of the plasma cells): 5 people, 17.24%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 13.79%
Immunodeficiency Common Variable: 4 people, 13.79%
Pain: 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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