Hyzaar and Dulcolax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hyzaar (hydrochlorothiazide; losartan potassium) and Dulcolax (bisacodyl). Common drug interactions include chest pain among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hyzaar and Dulcolax. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Dulcolax?

Dulcolax has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 12,897 Dulcolax users. Check the latest studies of Dulcolax.

On Jul, 11, 2026

31 people who take Hyzaar and Dulcolax together, and have interactions are studied.

What are the common drug interactions of Hyzaar and Dulcolax, by gender? *:

female:

Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Femur fracture
Foot fracture
Granuloma (a small area of inflammation due to tissue injury)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Metastases to bone (cancer spreads to bone)
Metastases to liver (cancer spreads to liver)
Obesity (having too much body fat)

male:

Fatigue (feeling of tiredness)
Pain
Back pain
Cartilage injury
Deafness unilateral
Dehydration (dryness resulting from the removal of water)
Haemorrhage (bleeding)
Herpes zoster
Mobility decreased (ability to move is reduced)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the common drug interactions of Hyzaar and Dulcolax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Death

20-29:

n/a

30-39:

Abdominal distension
Abdominal hernia
Abdominal pain
Arthralgia (joint pain)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone pain
Breast cancer
Cervicitis (inflammation of the uterine cervix)

40-49:

Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chest pain
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Femur fracture
Foot fracture
Granuloma (a small area of inflammation due to tissue injury)
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clumsiness (a lack of coordination or elegance)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Dysuria (painful or difficult urination)
Foot fracture
Herpes zoster
Mobility decreased (ability to move is reduced)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Poor venous access
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Rash

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 29.03%
Bone Loss: 8 people, 25.81%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.68%
Stress And Anxiety: 2 people, 6.45%
Renal Cell Carcinoma (a kidney cancer): 2 people, 6.45%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 6.45%
Pain: 2 people, 6.45%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.45%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.45%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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