Hyzaar and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hyzaar (hydrochlorothiazide; losartan potassium) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include infusion site haemorrhage among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hyzaar and Sudafed. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 10, 2026

15 people who take Hyzaar and Sudafed together, and have interactions are studied.

What are the common drug interactions of Hyzaar and Sudafed, by gender? *:

female:

Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Pruritus (severe itching of the skin)
Weight fluctuation
Allergic sinusitis
Hypersensitivity
Cough
Lacrimation increased
Seasonal allergy (allergic condition due to certain season)
Gastric disorder (disease of stomach)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Appetite disorder (abnormal eating habits)
Confusional state
Diarrhoea
Disturbance in attention
Hot flush (sudden feelings of heat)
Muscular weakness (muscle weakness)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Hyzaar and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Fatigue (feeling of tiredness)
Irritability
Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Sluggishness (lacking alertness)
Tension (the act or process of stretching something tight)
Weight decreased

50-59:

Aortic valve incompetence
Autoimmune hepatitis
Dizziness
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Herpes simplex (herpes simplex is a common viral infection)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nasopharyngitis (inflammation of the nasopharynx)
Neck mass (mass in neck)
Psoriasis (immune-mediated disease that affects the skin)
Sinusitis (inflammation of sinus)

60+:

Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Multiple allergies (allergy to multiple agents)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema lower limb (fluid collection in tissue of lower leg)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 33.33%
Sinusitis (inflammation of sinus): 3 people, 20.00%
Ulcer Haemorrhage (bleeding ulcer): 2 people, 13.33%
Thyroid Diseases: 2 people, 13.33%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 13.33%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Type 2 Diabetes: 1 person, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Hyzaar and Sudafed?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously