Hyzaar and Zyprexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hyzaar (hydrochlorothiazide; losartan potassium) and Zyprexa (olanzapine). Common drug interactions include abdominal pain among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Hyzaar and Zyprexa. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

On Jul, 06, 2026

71 people who take Hyzaar and Zyprexa together, and have interactions are studied.

What are the common drug interactions of Hyzaar and Zyprexa, by gender? *:

female:

Abdominal pain
Abdominal wall haematoma (abdominal wall blood clotting)
Abnormal behaviour
Adenoma benign (non-cancerous tumour -secreting)
Adverse drug reaction
Asthenia (weakness)
Asthma
Blood glucose increased
Blood triglycerides increased
Cardiac disorder

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Hepatitis c
Hyperkalaemia (damage to or disease of the kidney)
Mood swings (an extreme or rapid change in mood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Screaming (a long loud piercing cry)
Sedation
Sleep walking (walking during sleep)

What are the common drug interactions of Hyzaar and Zyprexa, by age (0-1 to 60+)? *:

0-1:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pulmonary embolism (blockage of the main artery of the lung)
Suicide attempt
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Type 2 diabetes mellitus

2-9:

n/a

10-19:

n/a

20-29:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus insulin-dependent
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug exposure during pregnancy
Gestational diabetes (diabetes in pregnancy)
Glucose urine present
Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Ketonuria (ketones in urine)
Polydipsia (excessive thirst)

30-39:

Type 2 diabetes mellitus
Obesity (having too much body fat)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Blood cholesterol increased
Diabetic coma
Hyperlipidaemia (presence of excess lipids in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Abdominal pain
Abdominal wall haematoma (abdominal wall blood clotting)
Chest pain

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Confusional state
Diabetes mellitus non-insulin-dependent
Headache (pain in head)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Pancreatitis acute (sudden inflammation of pancreas)
Post gastric surgery syndrome
Staphylococcal infection (an infection with staphylococcus bacteria)

50-59:

Cataract (clouding of the lens inside the eye)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Creatinine renal clearance decreased
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Diabetes mellitus non-insulin-dependent
Diabetic hyperglycaemic coma (diabetic coma occurs when blood sugar gets too high and the body becomes severely dehydrated)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diplopia (double vision)

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pubis fracture
Insomnia (sleeplessness)
Pneumonia
Psychomotor retardation (motor mental retardation)
Renal failure acute (rapid kidney dysfunction)
Accident
Adverse drug reaction
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture

What are the existing conditions these people have? *

Depression: 31 people, 43.66%
Pain: 7 people, 9.86%
Stress And Anxiety: 6 people, 8.45%
Sleep Disorder: 6 people, 8.45%
High Blood Cholesterol: 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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