Naprosyn and Ibrance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Ibrance (palbociclib). Common drug interactions include acute hepatic failure among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Ibrance. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Ibrance?

Ibrance has active ingredients of palbociclib. eHealthMe is studying from 104,434 Ibrance users. Check the latest studies of Ibrance.

On Apr, 29, 2026

33 people who take Naprosyn and Ibrance together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Ibrance, by gender? *:

female:

Acute hepatic failure
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemolytic anaemia (anaemia due to haemolysis)
Thrombocytopenia (decrease of platelets in blood)
Hepatitis (inflammation of the liver)
Diarrhoea
Hypersensitivity
Alopecia (absence of hair from areas of the body)
Disease progression
Fatigue (feeling of tiredness)

male:

Diarrhoea
Fall
Myopathy (a muscular disease in which the muscle fibres do not function)
Fatigue (feeling of tiredness)
Gait disturbance
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Sensory disturbance (sense disturbance)
Urinary retention (the inability to completely or partially empty the bladder)

What are the common drug interactions of Naprosyn and Ibrance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diarrhoea
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Sensory disturbance (sense disturbance)
Urinary retention (the inability to completely or partially empty the bladder)
Weight increased

40-49:

Acute hepatic failure
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemolytic anaemia (anaemia due to haemolysis)
Thrombocytopenia (decrease of platelets in blood)
Hepatitis (inflammation of the liver)
Disease progression
Hepatitis acute
Breast cancer metastatic
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
International normalised ratio increased

50-59:

Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone pain
Chest pain
Constipation
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Laziness

60+:

Diarrhoea
Alopecia (absence of hair from areas of the body)
Cough
Decreased appetite
Dental caries
Dry mouth
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Incision site erythema (redness of the skin at incision site)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 10 people, 30.30%
Breast Cancer Female: 7 people, 21.21%
Breast Cancer: 6 people, 18.18%
Nausea (feeling of having an urge to vomit): 3 people, 9.09%
Metastases To Bone (cancer spreads to bone): 3 people, 9.09%
Breast Cancer Stage Iv: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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