Ibu and Amrix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ibu (ibuprofen) and Amrix (cyclobenzaprine hydrochloride). Common drug interactions include uterine haemorrhage among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Ibu and Amrix. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

On Jul, 06, 2026

83 people who take Ibu and Amrix together, and have interactions are studied.

What are the common drug interactions of Ibu and Amrix, by gender? *:

female:

Uterine haemorrhage (uterine bleeding)
Abdominal pain upper
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Therapeutic response decreased (less preventive response)
Arthralgia (joint pain)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression

male:

Fatigue (feeling of tiredness)
Abasia (inability to walk)
Blood urea nitrogen/creatinine ratio increased
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Diastolic dysfunction
Gait disturbance
Globulins decreased
Haematocrit decreased
Haemoglobin decreased
Herpes zoster

What are the common drug interactions of Ibu and Amrix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Completed suicide (act of taking one's own life)
Multiple drug overdose intentional
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)

20-29:

n/a

30-39:

Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Chronic kidney disease
Cardiac failure
Dyspnoea (difficult or laboured respiration)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Drug ineffective
Emotional distress
General physical health deterioration (weak health status)
Injury
Lacrimation increased
Pain in extremity
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

Mania (a state of abnormally elevated or irritable mood)
Oral pain
Swelling
Tongue disorder (disease of tongue)
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Ankle fracture
Anxiety
Blood potassium decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Diastolic dysfunction
Gait disturbance
Heart rate irregular
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Pyrexia (fever)
Abasia (inability to walk)
Abdominal pain lower
Abdominal pain upper

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 42.17%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 33 people, 39.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 14.46%
High Blood Pressure: 11 people, 13.25%
Stress And Anxiety: 9 people, 10.84%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.84%
Diabetes: 6 people, 7.23%
Asthma: 6 people, 7.23%
Nightmares (unpleasant dreams): 5 people, 6.02%
Muscle Spasms (muscle contraction): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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