Imodium and Calcium ascorbate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Calcium ascorbate (vitamin c (ascorbic acid)). Common drug interactions include nausea among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Calcium ascorbate. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Calcium ascorbate?

Calcium ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,018 Calcium ascorbate users. Check the latest studies of Calcium ascorbate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

35 people who take Imodium and Calcium ascorbate together, and have interactions are studied.

Imodium and Calcium ascorbate drug interactions.

What are the common drug interactions of Imodium and Calcium Ascorbate, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain
Blood bilirubin increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hepatic enzyme increased
Hepatotoxicity (chemical-driven liver damage)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Jaundice cholestatic
Pneumonia

male:

Dizziness
Arthralgia (joint pain)
Hypersensitivity
Infusion related reaction
Joint swelling
Nausea (feeling of having an urge to vomit)
Pain
Pyrexia (fever)
Blood pressure diastolic increased
Blood pressure systolic increased

What are the common drug interactions of Imodium and Calcium Ascorbate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Throat irritation
Blood pressure increased
Chest discomfort
Cough
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)

60+:

Abdominal pain
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Anaemia (lack of blood)
Oesophageal candidiasis (fungal infection of oesophagus)
Ulcer haemorrhage (bleeding ulcer)
Abdominal discomfort
Abdominal distension

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 21 people, 60.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 22.86%
Constipation: 4 people, 11.43%
Psychotic Disorder: 3 people, 8.57%
Depression: 3 people, 8.57%
Pain In Extremity: 3 people, 8.57%
Pain: 3 people, 8.57%
Nausea (feeling of having an urge to vomit): 3 people, 8.57%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 3 people, 8.57%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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