Imodium and Clozapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Clozapine (clozapine). Common drug interactions include megacolon among females and gastroenteritis among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Clozapine. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

On Jul, 13, 2026

40 people who take Imodium and Clozapine together, and have interactions are studied.

Imodium and Clozapine drug interactions.

What are the common drug interactions of Imodium and Clozapine, by gender? *:

female:

Megacolon (a very dilated colon)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Intestinal obstruction
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Death
Drug ineffective
Drug level increased

male:

Gastroenteritis (inflammation of stomach and intestine)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Haematemesis (vomiting of blood)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Loss of consciousness
Lung disorder (lung disease)
Necrotising colitis (inflammation in the intestines (usually the colon) that can be life-threatening)

What are the common drug interactions of Imodium and Clozapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gastroenteritis (inflammation of stomach and intestine)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Intestinal obstruction
Abdominal distension
Anaemia (lack of blood)
Bacterial toxaemia (blood contains bacterial toxins)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Delirium (wild excitement)
Dissociative disorder
Drug level above therapeutic

40-49:

n/a

50-59:

Megacolon (a very dilated colon)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Intestinal obstruction
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Death
General physical health deterioration (weak health status)
Adenocarcinoma of the cervix (cervical cancer)
Anisocytosis (patient's red blood cells are of unequal size)
Dysmenorrhoea (painful menstruation)

60+:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Transaminases increased
Hepatocellular injury (liver injury)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Impaired self-care
Psychotic disorder
Weight increased
Urinary tract infection
Abdominal pain upper

What are the existing conditions these people have? *

Schizoaffective Disorder (a mental disorder characterized by disordered thought): 14 people, 35.00%
Pain: 5 people, 12.50%
Rashes (redness): 3 people, 7.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.50%
Insomnia (sleeplessness): 3 people, 7.50%
Fever: 3 people, 7.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 7.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 7.50%
Allergies: 3 people, 7.50%
Abdominal Discomfort: 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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